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Article

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.

Science (New York, N.Y.) - 9 Nov 2001

Shenoy S K, McDonald P H, Kohout T A, Lefkowitz R J

Abstract excerpt

Although trafficking and degradation of several membrane proteins are regulated by ubiquitination catalyzed by E3 ubiquitin ligases, there has been little evidence connecting ubiquitination with regulation of mammalian G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR) function. Agonist stimulation of endogenous or transfected beta2-adrenergic receptors (beta2ARs) led to rapid...

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Identifiers

PMID: 11588219
DOI: 10.1126/science.1063866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin.PMID 11588219Read ↗

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