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The α-Arrestin ARRDC3 Is an Emerging Multifunctional Adaptor Protein in Cancer

1 Sept 2021

Abstract excerpt

Significance: Adaptor proteins control the spatiotemporal dynamics of cellular signaling. Dysregulation of adaptor protein function can cause aberrant cell signaling and promote cancer. The arrestin family of adaptor proteins are known to regulate signaling by the superfamily of G protein-coupled receptors (GPCRs). The GPCRs are highly druggable and implicated in cancer progression. However, the molecular...

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PMID: 34465145
DOI: 10.1089/ars.2021.0193

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