An Intronic HCP5 Variant Is Associated With Age of Onset and Susceptibility to Graves Disease in UK and Polish Cohorts.

doi:10.1210/clinem/dgaa347

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An Intronic HCP5 Variant Is Associated With Age of Onset and Susceptibility to Graves Disease in UK and Polish Cohorts.

The Journal of clinical endocrinology and metabolism - 1 Sept 2020

Lane Laura Claire, Kuś Aleksander, Bednarczuk Tomasz, Bossowski Artur, Daroszewski Jacek, Jurecka-Lubieniecka Beata, Cordell Heather Jane, Pearce Simon Henry Schofield, Cheetham Timothy, Mitchell Anna Louise

Abstract excerpt

CONTEXT: The genetic background of young-onset Graves disease (GD) remains largely unknown. An intronic variant in human leukocyte antigen (HLA) complex P5 (HCP5) has previously been associated with GD susceptibility and age of onset in a cohort of Polish patients. OBJECTIVE: We aimed to investigate the association of the HCP5 variant rs3094228 with GD susceptibility and age of onset in a UK cohort and conduct a...

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PMID: 32501499
DOI: 10.1210/clinem/dgaa347
PMCID: PMC7382372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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