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Article

Association between complement gene polymorphisms and systemic lupus erythematosus: a systematic review and meta-analysis.

Clinical and experimental medicine - 1 Aug 2022

Ebrahimiyan Hamidreza, Mostafaei Shayan, Aslani Saeed, Faezi Seyedeh Tahereh, Farhadi Elham, Jamshidi Ahmadreza, Mahmoudi Mahdi

Abstract excerpt

Complement dysfunction results in impaired ability in clearing apoptotic cell debris that may stimulate autoantibody production in systemic lupus erythematosus (SLE). Herein, we provided a comprehensive search to find and meta-analyze any complement gene polymorphisms associated with SLE. The ITGAM, C1q, and MBL gene polymorphisms were included in this meta-analysis to reveal the exact association with SLE risk....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Genetic

Source

Identifiers

PMID: 34519938
DOI: 10.1007/s10238-021-00758-0

Genes

ITGAM
C1QA
MBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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