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Article

CYP3A variation and the evolution of salt-sensitivity variants.

American journal of human genetics - 1 Dec 2004

Thompson E E, Kuttab-Boulos H, Witonsky D, Yang L, Roe B A, Di Rienzo A

Abstract excerpt

Members of the cytochrome P450 3A subfamily catalyze the metabolism of endogenous substrates, environmental carcinogens, and clinically important exogenous compounds, such as prescription drugs and therapeutic agents. In particular, the CYP3A4 and CYP3A5 genes play an especially important role in pharmacogenetics, since they metabolize >50% of the drugs on the market. However, known genetic variants at these two...

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PMID: 15492926
DOI: 10.1086/426406
PMCID: PMC1182141

Genes

AGT

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