Article
Genome-Wide Association Study of Atorvastatin Pharmacokinetics: Associations With SLCO1B1, UGT1A3, and LPP.
Clinical pharmacology and therapeutics - 1 Jun 2024
Mykkänen Anssi J H, Tarkiainen E Katriina, Taskinen Suvi, Neuvonen Mikko, Paile-Hyvärinen Maria, Lilius Tuomas O, Tapaninen Tuija, Klein Kathrin, Schwab Matthias, Backman Janne T, Tornio Aleksi, Niemi Mikko
Abstract excerpt
In a genome-wide association study of atorvastatin pharmacokinetics in 158 healthy volunteers, the SLCO1B1 c.521T>C (rs4149056) variant associated with increased area under the plasma concentration-time curve from time zero to infinity (AUC0-∞) of atorvastatin (P = 1.2 × 10-10), 2-hydroxy atorvastatin (P = 4.0 × 10-8), and 4-hydroxy atorvastatin (P = 2.9 × 10-8). An intronic LPP variant, rs1975991, associated...
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