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Article

Evaluation of the relationship between sex, polymorphisms in CYP2C8 and CYP2C9, and pharmacokinetics of angiotensin receptor blockers.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2013

Cabaleiro Teresa, Román Manuel, Ochoa Dolores, Talegón María, Prieto-Pérez Rocío, Wojnicz Aneta, López-Rodríguez Rosario, Novalbos Jesús, Abad-Santos Francisco

Abstract excerpt

Angiotensin II receptor blockers (ARBs) are used to treat hypertension. Most ARBs are metabolized by CYP2C9. The aim of this study is to evaluate the possible association between sex, polymorphisms in the CYP2C8 and CYP2C9 genes, and the pharmacokinetics of losartan, valsartan, candesartan, and telmisartan. The study population comprised 246 healthy volunteers from seven single-dose clinical trials: 64 from two...

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Share to Angiotensin Receptor Antagonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C8

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Source

Identifiers

PMID: 23118328
DOI: 10.1124/dmd.112.046292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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