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Article

Effects of CYP3A41G and CYP3A53 polymorphisms on pharmacokinetics of tylerdipine hydrochloride in healthy Chinese subjects.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Mar 2019

Zhou Sufeng, Tao Mingxue, Wang Yuanyuan, Wang Lu, Xie Lijun, Chen Juan, Zhao Yuqing, Liu Yun, Zhang Hongwen, Ou Ning, Wang Guangji, Shao Feng, Aa Jiye

Abstract excerpt

The aim of this analysis was to explore the influence of CYP3A4*1G and CYP3A5*3 polymorphisms on the pharmacokinetics of tylerdipine in healthy Chinese subjects. A total of 64 and 63 healthy Chinese subjects were included and identified as the genotypes of CYP3A4*1G and CYP3A5*3, respectively. Plasma samples were collected for up to 120 h post-dose to characterize the pharmacokinetic profile following single oral...

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Identifiers

PMID: 29521134
DOI: 10.1080/00498254.2018.1447711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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