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Article

Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Kawano Shin, Yamano Koji, Naoé Mari, Momose Takaki, Terao Kayoko, Nishikawa Shuh-ichi, Watanabe Nobuhisa, Endo Toshiya

Abstract excerpt

The mitochondrial intermembrane space (IMS) contains many small cysteine-bearing proteins, and their passage across the outer membrane and subsequent folding require recognition and disulfide bond transfer by an oxidative translocator Tim40/Mia40 in the inner membrane facing the IMS. Here we determined the crystal structure of the core domain of yeast Mia40 (Mia40C4) as a fusion protein with maltose-binding...

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Identifiers

PMID: 19667201
DOI: 10.1073/pnas.0901793106
PMCID: PMC2732879

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