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Eras of designer Tregs: Harnessing synthetic biology for immune suppression

31 Jul 2023

Abstract excerpt

regulatory T cells (Tregs) have been firmly established as a critical cell type for regulating immune homeostasis through a plethora of mechanisms. Due to their immunoregulatory power, delivery of polyclonal Tregs has been explored as a therapy to dampen inflammation in the settings of transplantation and autoimmunity. Evidence shows that Treg therapy is safe and well-tolerated, but efficacy remains undefined and...

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PMID: 37522861
DOI: 10.1111/imr.13254

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