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Article

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism.

Nature communications - 1 Jun 2020

Williams Kristine, Ingerslev Lars R, Bork-Jensen Jette, Wohlwend Martin, Hansen Ann Normann, Small Lewin, Ribel-Madsen Rasmus, Astrup Arne, Pedersen Oluf, Auwerx Johan, Workman Christopher T, Grarup Niels, Hansen Torben, Barrès Romain

Abstract excerpt

Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factors that are characterized by insulin resistance in skeletal muscle, a prominent site of glucose disposal. Numerous genetic variants have been associated with obesity and T2D, of which the majority are located in non-coding DNA regions. This suggests that most variants mediate their effect by altering the activity of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32483258
DOI: 10.1038/s41467-020-16537-6
PMCID: PMC7264154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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