Article

Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue

2025-10-12

Abstract excerpt

White adipose tissue (WAT) dysfunction contributes to obesity-associated metabolic disease and type 2 diabetes (T2D). Rodent studies have demonstrated that exercise training improves WAT function, but molecular studies investigating exercise training effects on WAT in humans have been limited, particularly in the context of metabolic disease. Here, we defined the subcutaneous WAT (scWAT) transcriptome in middle-ag...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 12e5bb06-aa24-5884-a0e8-367218339f6c
DOI: 10.1101/2025.10.11.681273

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose TissueDOI 10.1101/2025.10.11.681273Read

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissueSemantic proximity Read

Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic DysfunctionSemantic proximity Read

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytesSemantic proximity Read

High-throughput proteomics uncovers exercise training and type 2 diabetes–induced changes in human white adipose tissueSemantic proximity Read

Transcriptional dynamics in type 2 diabetes progression is linked with circadian, thermogenic, and cellular stress in human adipose tissueSemantic proximity Read

Conserved multi-tissue transcriptomic adaptations to exercise training in humans and miceSemantic proximity Read

Temporal dynamics of the multi-omic response to endurance exercise training across tissuesSemantic proximity Read

Common and ethnic-specific derangements in skeletal muscle transcriptome associated with obesity.Semantic proximity Read

A conserved transcriptomic model defines metabolic resilience and vulnerability in obesitySemantic proximity Read

Integrated miRNA–mRNA Analysis Reveals Dysregulated Regulatory Networks in Visceral Adipose Tissue Linked to Obesity and Type 2 DiabetesSemantic proximity Read

Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a 6‐month exercise interventionSemantic proximity Read

Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in HumansSemantic proximity Read