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Article

Skeletal muscle enhancer programming of cardiorespiratory fitness

2025-10-03

Abstract excerpt

Cardiorespiratory fitness (CRF) is a heritable trait associated with improved metabolic health and longevity. To identify regulatory mechanisms underlying CRF, we integrated 546 transcriptomic and epigenomic profiles from skeletal muscle of 128 genetically heterogeneous rats selectively bred for high and low running capacity, a model that mirrors CRF-associated traits in humans. Selection drove genetic convergence...

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Literature Corpus work
246ea24f-3348-5eff-8b6a-b226bd5aa67c
DOI
10.1101/2025.10.02.679855
Open publication

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Skeletal muscle enhancer programming of cardiorespiratory fitnessDOI 10.1101/2025.10.02.679855
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