Article
A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous cell carcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2018
Li X C, Wang M Y, Yang M, Dai H J, Zhang B F, Wang W, Chu X L, Wang X, Zheng H, Niu R F, Zhang W, Chen K X
Abstract excerpt
Background: Esophageal squamous cell carcinoma (ESCC) is often diagnosed at an advanced and incurable stage. Information on driver genes and prognosticators in ESCC remains incomplete. The objective was to elucidate significantly mutated genes (SMGs), mutational signatures, and prognosticators in ESCC. Patients and methods: Three MutSig algorithms (i.e. MutSigCV, MutSigCL and MutSigFN) and '20/20+' ratio-metric...
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