Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal relationship and alcohol consumption-associated mutational signature in synchronous hypopharyngeal tumours and oesophageal squamous cell carcinoma.

British journal of cancer - 1 Dec 2022

Ko Josephine Mun-Yee, Guo Chen, Liu Conghui, Ning Lvwen, Dai Wei, Tao Lihua, Lo Anthony Wing-Ip, Wong Carissa Wing-Yan, Wong Ian Yu-Hong, Chan Fion Siu-Yin, Wong Claudia Lai-Yin, Chan Kwan Kit, Law Tsz Ting, Lee Nikki Pui-Yue, Liu Zhichao, Jiang Haoyao, Li Zhigang, Law Simon, Lung Maria Li

Abstract excerpt

BACKGROUND: The patients with dual oesophageal squamous cell carcinoma (ESCC) and hypopharyngeal cancer (HPC) have poor prognosis; their underlying genetic pathogenesis is unclear. We hypothesise that development of synchronous ESCC/HPC depends on multicentricity or independent origin, rather than multifocality due to local or lateral spreading. METHOD: Multiple region whole-exome sequencing (M-WES) and clonality...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Cancer Genomics and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Esophageal Cancer Research and Treatment

Share to Esophageal Neoplasms

Share to Esophageal Squamous Cell Carcinoma

Share to Head and Neck Cancer Studies

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 36261585
DOI: 10.1038/s41416-022-01995-0
PMCID: PMC9726980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal relationship and alcohol consumption-associated mutational signature in synchronous hypopharyngeal tumours and oesophageal squamous cell carcinoma.PMID 36261585Read ↗

Comprehensive analysis reveals distinct mutational signature and its mechanistic insights of alcohol consumption in human cancers.Semantic proximity Read ↗

Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell CarcinomaSemantic proximity Read ↗

Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations.Semantic proximity Read ↗

Comparison of Somatic Mutations in Primary Squamous Cell Carcinomas of the Hypopharynx and the Esophagus Developed in Individual Patients.Semantic proximity Read ↗

Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma.Semantic proximity Read ↗

Genomic Alterations in Oral Multiple Primary CancersSemantic proximity Read ↗

A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous cell carcinoma.Semantic proximity Read ↗

Somatic mosaicism in the buccal mucosa reflects lifestyle and germline risk factors for esophageal squamous cell carcinomaSemantic proximity Read ↗

Intratumoural heterogeneity and clone evolution of oral squamous cell carcinoma.Semantic proximity Read ↗

Alcohol Consumption, ALDH2 Polymorphism as Risk Factors for Upper Aerodigestive Tract Cancer Progression and PrognosisSemantic proximity Read ↗

Molecular evolution in different subtypes of multifocal hepatocellular carcinomaSemantic proximity Read ↗

Multiple region whole-exome sequencing reveals dramatically evolving intratumor genomic heterogeneity in esophageal squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.