Article
Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations.
Nature communications - 26 May 2017
Chang Jiang, Tan Wenle, Ling Zhiqiang, Xi Ruibin, Shao Mingming, Chen Mengjie, Luo Yingying, Zhao Yanjie, Liu Yun, Huang Xiancong, Xia Yuchao, Hu Jinlin, Parker Joel S, Marron David, Cui Qionghua, Peng Linna, Chu Jiahui, Li Hongmin, Du Zhongli, Han Yaling, Tan Wen, Liu Zhihua, Zhan Qimin, Li Yun, Mao Weimin, Wu Chen, Lin Dongxin
Abstract excerpt
Approximately half of the world's 500,000 new oesophageal squamous-cell carcinoma (ESCC) cases each year occur in China. Here, we show whole-genome sequencing of DNA and RNA in 94 Chinese individuals with ESCC. We identify six mutational signatures (E1-E6), and Signature E4 is unique in ESCC linked to alcohol intake and genetic variants in alcohol-metabolizing enzymes. We discover significantly recurrent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.