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A TOMM40/APOE allele encoding APOE-E3 predicts high likelihood of late-onset Alzheimer's disease in autopsy cases.

Molecular genetics & genomic medicine - 1 Aug 2020

Soyal Selma M, Kwik Markus, Kalev Ognian, Lenz Stefan, Zara Greta, Strasser Peter, Patsch Wolfgang, Weis Serge

Abstract excerpt

BACKGROUND: The APOE-ε4 allele is an established risk factor for Alzheimer's disease (AD). TOMM40 located adjacent to APOE has also been implicated in AD but reports of TOMM40 associations with AD that are independent of APOE-ε4 are at variance. METHODS: We investigated associations of AD with haplotypes defined by three TOMM40 and two APOE single nucleotide polymorphisms in 73 and 71 autopsy cases with...

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Identifiers

PMID: 32472747
DOI: 10.1002/mgg3.1317
PMCID: PMC7434743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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