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Article

Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association.

Genomics - 1 Jun 2007

Yu Chang-En, Seltman Howard, Peskind Elaine R, Galloway Nichole, Zhou Peter X, Rosenthal Elisabeth, Wijsman Ellen M, Tsuang Debby W, Devlin Bernie, Schellenberg Gerard D

Abstract excerpt

The epsilon(4) allele of APOE confers a two- to fourfold increased risk for late-onset Alzheimer's disease (LOAD), but LOAD pathology does not all fit neatly around APOE. It is conceivable that genetic variation proximate to APOE contributes to LOAD risk. Therefore, we investigated the degree of...

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Source

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Identifiers

PMID: 17434289
DOI: 10.1016/j.ygeno.2007.02.002
PMCID: PMC1978251

Genes

APOE
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17434289-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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