Article
Expanding horizons for receptors coupled to G proteins: diversity and disease.
Current opinion in cell biology - 1 Apr 1994
Coughlin S R
Abstract excerpt
The known repertoire of seven transmembrane domain receptors coupled to G proteins has expanded in several interesting directions. Both loss-of-function and activating mutations have been found at the root of a variety of diseases. More will undoubtedly be uncovered. The diversity of ligands which trigger G protein coupled receptors continues to grow, and with it the variety of known strategies for ligand...
Topics
- Alternative Splicing
- Animals
- GTP-Binding Proteins
- Genetic Diseases, Inborn
- Humans
- Models, Structural
- Mutation
- Protein Structure, Secondary
- Receptors, Cell Surface