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Article

Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer’s disease

3 Nov 2018

Abstract excerpt

BACKGROUND: Biomarkers that can track disease onset and progression in autosomal dominant Alzheimer's disease (ADAD) are needed. We investigate whether serum neurofilament light (NfL) concentration is associated with clinical and cerebrospinal fluid (CSF) markers in ADAD. We also evaluate serum NfL differences between clinical groups. METHODS: Serum NfL was measured cross-sectionally in 60 individuals from ADAD...

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PMID: 30390718
DOI: 10.1186/s13195-018-0439-y

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