Impact of APOE ε4 and ε2 on plasma neurofilament light chain and cognition in autosomal dominant Alzheimer's disease.

doi:10.1186/s13195-024-01572-y

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Article

Impact of APOE ε4 and ε2 on plasma neurofilament light chain and cognition in autosomal dominant Alzheimer's disease.

Alzheimer's research & therapy - 1 Oct 2024

Langella Stephanie, Bonta Kyra, Chen Yinghua, Su Yi, Vasquez Daniel, Aguillon David, Acosta-Baena Natalia, Baena Ana Y, Garcia-Ospina Gloria, Giraldo-Chica Margarita, Tirado Victoria, Muñoz Claudia, Ríos-Romenets Silvia, Guzman-Martínez Claudia, Pruzin Jeremy J, Ghisays Valentina, Arboleda-Velasquez Joseph F, Kosik Kenneth S, Tariot Pierre N, Reiman Eric M, Lopera Francisco, Quiroz Yakeel T

Abstract excerpt

BACKGROUND: Apolipoprotein E (APOE) genotypes have been suggested to influence cognitive impairment and clinical onset in presenilin-1 (PSEN1) E280A carriers for autosomal dominant Alzheimer's disease (ADAD). Less is known about their impact on the trajectory of biomarker changes. Neurofilament light chain (NfL), a marker of neurodegeneration, begins to accumulate in plasma about 20 years prior to the clinical...

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Identifiers

PMID: 39354618
DOI: 10.1186/s13195-024-01572-y
PMCID: PMC11443799

Genes

APOE
PSEN1

Variants

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