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Article

MiRNA-based model for predicting the TMB level in colon adenocarcinoma based on a LASSO logistic regression method.

Medicine - 28 May 2021

Li Zhengtian, Jiang Lingling, Zhao Rong, Huang Jun, Yang Wenkang, Wen Zhenpei, Zhang Bo, Du Gang

Abstract excerpt

ABSTRACT: Some patients with advanced colon adenocarcinoma (COAD) are not sensitive to radiotherapy and chemotherapy, and as such, immunotherapy has become the most popular option for these patients. However, different patients respond differently to immunotherapy. Tumor mutational burden (TMB) has been used as a predictor of the response of advanced COAD patients to immunotherapy. A high TMB typically indicates...

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Identifiers

PMID: 34032736
DOI: 10.1097/MD.0000000000026068
PMCID: PMC8154456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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