Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancer

9 Apr 2021

Abstract excerpt

Abstract Identifying robust predictive biomarkers to stratify colorectal cancer (CRC) patients based on their response to immune-checkpoint therapy is an area of unmet clinical need. Our evolutionary algorithm Atlas Correlation Explorer (ACE) represents a novel approach for mining The Cancer Genome Atlas (TCGA) data for clinically relevant associations. We deployed ACE to identify candidate predictive biomarkers...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Colorectal Cancer Treatments and Studies
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33928242
DOI: 10.1093/nargab/lqab016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary genetic algorithm identifies IL2RB as a potential predictive biomarker for immune-checkpoint therapy in colorectal cancerPMID 33928242Read ↗

High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer.Semantic proximity Read ↗

Identification and validation of an immune-related gene signature predictive of overall survival in colon cancerSemantic proximity Read ↗

An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapySemantic proximity Read ↗

Prognostic and immunotherapeutic significance of immunogenic cell death-related genes in colon adenocarcinoma patientsSemantic proximity Read ↗

Identification and Validation of Immune Molecular Subtypes and Immune Landscape Based on Colon Cancer CohortSemantic proximity Read ↗

PRKCB is a novel and potential biomarker in colon cancer and shapes an inflamed tumor immune microenvironmentSemantic proximity Read ↗

How Can We Improve Subtyping of Colon Adenocarcinoma for Precision Oncology? Multi-Omics Consensus Clustering Reveals Immunologically Active and Therapeutically Distinct Molecular Groups.Semantic proximity Read ↗

Genetic variations in the CTLA-4 immune checkpoint pathway are associated with colon cancer risk, prognosis, and immune infiltration via regulation of IQCB1 expression.Semantic proximity Read ↗

Identification of an immune checkpoint gene signature that accurately predicts prognosis and immunotherapy response in endometrial carcinoma.Semantic proximity Read ↗

ALOX12: A Novel Insight in Bevacizumab Response, Immunotherapy Effect, and Prognosis of Colorectal CancerSemantic proximity Read ↗

Identification of a Tumor Microenvironment‐Related Gene Signature Indicative of Disease Prognosis and Treatment Response in Colon CancerSemantic proximity Read ↗

Integrating tumor mutational burden and transcriptome expression into prediction of immune checkpoint inhibitor response and prognosis of patients with colon cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.