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Article

m6A-binding YTHDF proteins promote stress granule formation.

Nature chemical biology - 1 Sept 2020

Fu Ye, Zhuang Xiaowei

Abstract excerpt

Diverse RNAs and RNA-binding proteins form phase-separated, membraneless granules in cells under stress conditions. However, the role of the prevalent mRNA methylation, m6A, and its binding proteins in stress granule (SG) assembly remain unclear. Here, we show that m6A-modified mRNAs are enriched in SGs, and that m6A-binding YTHDF proteins are critical for SG formation. Depletion of YTHDF1/3 inhibits SG formation...

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Identifiers

PMID: 32451507
DOI: 10.1038/s41589-020-0524-y
PMCID: PMC7442727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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