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Article

GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a β1-Integrin Pathway

1 Jan 2020

Abstract excerpt

BACKGROUND & AIMS: Transforming growth factor (TGF-β)-induced activation of quiescent hepatic stellate cells (HSCs) and their transformation to myofibroblasts is a key event in liver fibrosis and portal hypertension. GIPC (also referred to as synectin) is a downstream signal activation molecule of TGF-β and other receptors. In this study, we sought to identify novel genes targeted by TGF-β and GIPC and elucidate...

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Share to Growth Hormone and Insulin-like Growth Factors
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PMID: 32447051
DOI: 10.1016/j.jcmgh.2020.05.005

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