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The role of TGFBI (βig-H3) in gastrointestinal tract tumorigenesis

23 Mar 2015

Abstract excerpt

BACKGROUND: TGFβ-induced (TGFBI/βig-H3) is a protein inducible by TGFβ1 and secreted by many types of cells. It binds to collagen, forms part of the extracellular matrix (ECM), and interacts with integrins on cell surfaces. In this study, we investigated the role of TGFBI in tumorigenesis and the underlying mechanisms. METHODS: Patient serum TGFBI levels were determined by ELISA. TGFBI transgenic and gene...

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PMID: 25889002
DOI: 10.1186/s12943-015-0335-z

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