Article

STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer

2024-04-04

Abstract excerpt

Oncogenic mutations in KRAS are among the most common in cancer. Classical models suggest that loss of epithelial characteristics and the acquisition of mesenchymal traits are associated with cancer aggressiveness and therapy resistance. However, the mechanistic link between these phenotypes and mutant KRAS biology remains to be established. Here, we identify STAT3 as a genetic modifier of TGF-beta-induced epithel...

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Literature Corpus work: 785606b5-1e5e-59af-add1-2d2d98a5bbcf
DOI: 10.7554/elife.92559.2

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