Article
Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk.
JAMA neurology - 1 Oct 2013
Moskvina Valentina, Harold Denise, Russo GianCarlo, Vedernikov Alexey, Sharma Manu, Saad Mohamed, Holmans Peter, Bras Jose M, Bettella Francesco, Keller Margaux F, Nicolaou Nayia, Simón-Sánchez Javier, Gibbs J Raphael, Schulte Claudia, Durr Alexandra, Guerreiro Rita, Hernandez Dena, Brice Alexis, Stefánsson Hreinn, Majamaa Kari, Gasser Thomas, Heutink Peter, Wood Nick, Martinez Maria, Singleton Andrew B, Nalls Michael A, Hardy John, Owen Michael J, O'Donovan Michael C, Williams Julie, Morris Huw R, Williams Nigel M
Abstract excerpt
IMPORTANCE: Despite Alzheimer disease (AD) and Parkinson disease (PD) being clinically distinct entities, there is a possibility of a pathological overlap, with some genome-wide association (GWA) studies suggesting that the 2 diseases represent a biological continuum. The application of GWA studies to idiopathic forms of AD and PD have identified a number of loci that contain genetic variants that increase the...
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