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Article

Extracellular vesicles from genetically unstable, oncogene-driven cancer cells trigger micronuclei formation in endothelial cells.

Scientific reports - 22 May 2020

Chennakrishnaiah Shilpa, Tsering Thupten, Gregory Caroline, Tawil Nadim, Spinelli Cristiana, Montermini Laura, Karatzas Nicolaos, Aprikian Saro, Choi Dongsic, Klewes Ludger, Mai Sabine, Rak Janusz

Abstract excerpt

Oncogenic transformation impacts cancer cell interactions with their stroma, including through formation of abnormal blood vessels. This influence is often attributed to angiogenic growth factors, either soluble, or associated with tumor cell-derived extracellular vesicles (EVs). Here we examine some of the cancer-specific components of EV-mediated tumor-vascular interactions, including the impact of genetic...

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Share to Cell Transformation, Neoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Micronuclei, Chromosome-Defective

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Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 32444772
DOI: 10.1038/s41598-020-65640-7
PMCID: PMC7244541

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