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Oncogenic Regulation of Extracellular Vesicle Proteome and Heterogeneity

18 Dec 2018

Abstract excerpt

Mutational and epigenetic driver events profoundly alter intercellular communication pathways in cancer. This effect includes deregulated release, molecular composition, and biological activity of extracellular vesicles (EVs), membranous cellular fragments ranging from a few microns to less than 100 nm in diameter and filled with bioactive molecular cargo (proteins, lipids, and nucleic acids). While EVs are...

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PMID: 30561828
DOI: 10.1002/pmic.201800169

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