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Article

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation

28 Nov 2022

Abstract excerpt

Introduction: Enterovirus infection has long been suspected as a possible trigger for type 1 diabetes. Upon infection, viral double-stranded RNA (dsRNA) is recognized by membrane and cytosolic sensors that orchestrate type I interferon signaling and the recruitment of innate immune cells to the pancreatic islets. In this context, adenosine deaminase acting on RNA 1 (ADAR1) editing plays an important role in...

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PMID: 36518246
DOI: 10.3389/fendo.2022.1058345

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