Article
A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters.
American journal of physiology. Endocrinology and metabolism - 1 Jul 2005
Peeters Robin P, van den Beld Annewieke W, Attalki Hayat, Toor Hans van, de Rijke Yolanda B, Kuiper George G J M, Lamberts Steven W J, Janssen Joop A M J L, Uitterlinden Andre G, Visser Theo J
Abstract excerpt
Type II deiodinase (D2) is important in the regulation of local thyroid hormone bioactivity in certain tissues. D2 in skeletal muscle may also play a role in serum triiodothyronine (T(3)) production. In this study, we identified a polymorphism in the 5'-UTR of the D2 gene (D2-ORFa-Gly3Asp). We investigated the association of D2-ORFa-Gly3Asp, and of the previously identified D2-Thr92Ala polymorphism, with serum...
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