ALPS: an autoimmune human lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis.

Abstract excerpt

Apoptosis of activated lymphocytes is critical to immune homeostasis. The cell surface receptor Fas is an important mediator of lymphocyte apoptosis; defective Fas expression causes accumulation of lymphocytes and autoimmune disease in mice. Apoptosis defects due to mutations of Fas have also been found in a rare human autoimmune lymphoproliferative syndrome (ALPS). Nine unrelated children with ALPS had...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis
• Share to Autoimmune Diseases
• Share to Child, Preschool