ALPS: an autoimmune human lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis.

doi:10.1006/smim.1996.0056

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Article

ALPS: an autoimmune human lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis.

Seminars in immunology - 1 Feb 1997

Puck J M, Sneller M C

Abstract excerpt

Apoptosis of activated lymphocytes is critical to immune homeostasis. The cell surface receptor Fas is an important mediator of lymphocyte apoptosis; defective Fas expression causes accumulation of lymphocytes and autoimmune disease in mice. Apoptosis defects due to mutations of Fas have also bee...

Topics

Apoptosis
Autoimmune Diseases
Child, Preschool
Female
Humans
Infant
Lymphocytes
Lymphoproliferative Disorders
Male
Mutation
Signal Transduction
Splenectomy
fas Receptor

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