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Article

ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin

8 May 2020

Abstract excerpt

Zinc finger protein with KRAB and SCAN domains 3 (ZKSCAN3) has long been known as a master transcriptional repressor of autophagy. Here, we identify a novel role for ZKSCAN3 in alleviating senescence that is independent of its autophagy-related activity. Downregulation of ZKSCAN3 is observed in aged human mesenchymal stem cells (hMSCs) and depletion of ZKSCAN3 accelerates senescence of these cells....

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Share to Epigenetics and DNA Methylation
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PMID: 32427330
DOI: 10.1093/nar/gkaa425

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