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Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation

26 Jan 2021

Abstract excerpt

Telomeres are organized into a heterochromatin structure and maintenance of silent heterochromatin is required for chromosome stability. How telomere heterochromatin is dynamically regulated in response to stimuli remains unknown. Pyruvate kinase Pyk1 forms a complex named SESAME (Serine-responsive SAM-containing Metabolic Enzyme complex) to regulate gene expression by phosphorylating histone H3T11 (H3pT11)....

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PMID: 33500413
DOI: 10.1038/s41467-020-20711-1

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