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Article

SIRT3 consolidates heterochromatin and counteracts senescence

1 Mar 2021

Abstract excerpt

Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of physiological and pathological processes, including aging and aging-related diseases. However, the role of SIRT3 in regulating human stem cell homeostasis remains unclear. Here we found that SIRT3 expression was downregulated in senescent human mesenchymal stem cells (hMSCs). CRISPR/Cas9-mediated depletion of SIRT3 led to compromised...

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PMID: 33706382
DOI: 10.1093/nar/gkab161

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