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Article

Protein frustratometer: a tool to localize energetic frustration in protein molecules.

Nucleic acids research - 1 Jul 2012

Jenik Michael, Parra R Gonzalo, Radusky Leandro G, Turjanski Adrian, Wolynes Peter G, Ferreiro Diego U

Abstract excerpt

The frustratometer is an energy landscape theory-inspired algorithm that aims at quantifying the location of frustration manifested in protein molecules. Frustration is a useful concept for gaining insight to the proteins biological behavior by analyzing how the energy is distributed in protein structures and how mutations or conformational changes shift the energetics. Sites of high local frustration often...

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Identifiers

PMID: 22645321
DOI: 10.1093/nar/gks447
PMCID: PMC3394345

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