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Article

Systemic deletion of Atp7b modifies the hepatocytes' response to copper overload in the mouse models of Wilson disease.

Scientific reports - 11 Mar 2021

Muchenditsi Abigael, Talbot C Conover, Gottlieb Aline, Yang Haojun, Kang Byunghak, Boronina Tatiana, Cole Robert, Wang Li, Dev Som, Hamilton James P, Lutsenko Svetlana

Abstract excerpt

Wilson disease (WD) is caused by inactivation of the copper transporter Atp7b and copper overload in tissues. Mice with Atp7b deleted either globally (systemic inactivation) or only in hepatocyte recapitulate various aspects of human disease. However, their phenotypes vary, and neither the common response to copper overload nor factors contributing to variability are well defined. Using metabolic, histologic, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33707579
DOI: 10.1038/s41598-021-84894-3
PMCID: PMC7952580

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