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Mitochondrially Transcribed dsRNA Mediates Manganese-induced Neuroinflammation

2025-02-20

Abstract excerpt

Manganese is an essential trace element required for various biological functions, but in excess is neurotoxic and leads to significant health concerns. The mechanisms underlying manganese neurotoxicity remain poorly understood. Neuropathological studies of affected brain regions reveal astrogliosis, neuronal loss, and neuroinflammation. Here, we present a novel manganese-dependent mechanism linking mitochondrial...

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Literature Corpus work
ab45821d-3a35-5139-8719-6b0a419203ef
DOI
10.1101/2025.02.16.638529
Open publication

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Mitochondrially Transcribed dsRNA Mediates Manganese-induced NeuroinflammationDOI 10.1101/2025.02.16.638529
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