Article
Somatic mutations in a multigene panel and impact on prognosis based on TP53 status in Chinese HER2-positive patients undergoing neoadjuvant therapy: A single-institution retrospective cohort.
Cancer medicine - 1 Jan 2024
Xiong Min, Wang Xuliren, Liu Douwaner, Xiu Bingqiu, Zhang Qi, Chi Weiru, Goh Chih Wan, Zhang Liyi, Chen Ming, Ren Hengyu, Shao Zhi-Ming, Yang Benlong, Wu Jiong
Abstract excerpt
BACKGROUND: Gene mutations play a crucial role in the occurrence and development of tumors, particularly in breast cancer (BC). Neoadjuvant therapy (NAT) has shown greater clinical benefit in HER2-positive breast cancer. However, further clinical investigation is needed to fully understand the correlation between genetic mutations and NAT efficacy and the long-term prognosis in HER2-positive BC. METHODS: This was...
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