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Article

Kinetics of pHLIP peptide insertion into and exit from a membrane.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2020

Slaybaugh Gregory, Weerakkody Dhammika, Engelman Donald M, Andreev Oleg A, Reshetnyak Yana K

Abstract excerpt

To advance mechanistic understanding of membrane-associated peptide folding and insertion, we have studied the kinetics of three single tryptophan pHLIP (pH-Low Insertion Peptide) variants, where tryptophan residues are located near the N terminus, near the middle, and near the inserting C-terminal end of the pHLIP transmembrane helix. Single-tryptophan pHLIP variants allowed us to probe different parts of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32409607
DOI: 10.1073/pnas.1917857117
PMCID: PMC7275707

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