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Article

Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons?

Neuron - 12 Sept 2002

Xiong Zhi-Qi, McNamara James O

Abstract excerpt

The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked mutant forms of superoxide dismutase 1 (SOD1) exhibit an increased sensitivity to death triggered...

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Source

Identifiers

PMID: 12354390
DOI: 10.1016/s0896-6273(02)00910-8

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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