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Article

Late-onset motoneuron disease caused by a functionally modified AMPA receptor subunit

12 Apr 2005

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating disorder of the central nervous system in middle and old age that leads to progressive loss of spinal motoneurons. Transgenic mice overexpressing mutated human Cu(2+)/Zn(2+) superoxide dismutase 1 (SOD1) reproduce clinical features of the familial form of ALS. However, changes in SOD1 activity do not correlate with severity of motor decline in sporadic cases,...

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PMID: 15827116
DOI: 10.1073/pnas.0501316102

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