Article
Pericytes Extend Survival of ALS SOD1 Mice and Induce the Expression of Antioxidant Enzymes in the Murine Model and in IPSCs Derived Neuronal Cells from an ALS Patient.
Stem cell reviews and reports - 1 Oct 2017
Coatti Giuliana Castello, Frangini Miriam, Valadares Marcos C, Gomes Juliana Plat, Lima Natalia O, Cavaçana Natale, Assoni Amanda F, Pelatti Mayra V, Birbrair Alexander, de Lima Antonio Carlos Pedroso, Singer Julio M, Rocha Francisco Marcelo M, Da Silva Giovani Loiola, Mantovani Mario Sergio, Macedo-Souza Lucia Inês, Ferrari Merari F R, Zatz Mayana
Abstract excerpt
Amyotrophic Lateral Sclerosis (ALS) is one of the most common adult-onset motor neuron disease causing a progressive, rapid and irreversible degeneration of motor neurons in the cortex, brain stem and spinal cord. No effective treatment is available and cell therapy clinical trials are currently being tested in ALS affected patients. It is well known that in ALS patients, approximately 50% of pericytes from the...
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