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Article

Nonalcoholic fatty liver disease in CLOCK mutant mice.

The Journal of clinical investigation - 3 Aug 2020

Pan Xiaoyue, Queiroz Joyce, Hussain M Mahmood

Abstract excerpt

Nonalcoholic fatty liver disease (NAFLD) is becoming a major health issue as obesity increases around the world. We studied the effect of a circadian locomotor output cycles kaput (CLOCK) mutant (ClkΔ19/Δ19) protein on hepatic lipid metabolism in C57BL/6 Clkwt/wt and apolipoprotein E-deficient (Apoe-/-) mice. Both ClkΔ19/Δ19 and ClkΔ19/Δ19 Apoe-/- mice developed a full spectrum of liver diseases (steatosis,...

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CLOCK Proteins
Disease Models, Animal
Enhancer Elements, Genetic
Mice
Mice, Knockout, ApoE

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Non-alcoholic Fatty Liver Disease

Protein Domains

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Identifiers

PMID: 32396530
DOI: 10.1172/JCI132765
PMCID: PMC7410080

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