Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice.

Abstract excerpt

OBJECTIVE: Circadian Clock gene mutant mice show dampened 24-h feeding rhythms and an increased sensitivity to high-fat diet (HFD) feeding. Restricting HFD access to the dark phase counteracts its obesogenic effect in wild-type mice. The extent to which altered feeding rhythms are causative for the obesogenic phenotype of Clock mutant mice, however, remains unknown. METHODS: Metabolic parameters of wild-type (WT)...

Topics

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• CLOCK Proteins
• Diet, High-Fat
• Feeding Behavior
• Genetic Therapy
• Hyperphagia