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Article

Increased expression of enzymes of triglyceride synthesis is essential for the development of hepatic steatosis.

Cell reports - 28 Mar 2013

Jin Jingling, Iakova Polina, Breaux Meghan, Sullivan Emily, Jawanmardi Nicole, Chen Dahu, Jiang Yanjun, Medrano Estela M, Timchenko Nikolai A

Abstract excerpt

Molecular mechanisms underpinning nonalcoholic fatty liver disease (NAFLD) are not well understood. The earliest step of NAFLD is hepatic steatosis, which is one of the main characteristics of aging liver. Here, we present a molecular scenario of age-related liver steatosis. We show that C/EBPα-S193D knockin mice have age-associated epigenetic changes and develop hepatic steatosis at 2 months of age. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23499441
DOI: 10.1016/j.celrep.2013.02.009
PMCID: PMC3615099

Genes

EBP

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