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Article

Circadian mutant mice with obesity and metabolic syndrome are resilient to cardiovascular disease.

American journal of physiology. Heart and circulatory physiology - 1 Nov 2020

Reitz Cristine J, Alibhai Faisal J, de Lima-Seolin Bruna Gazzi, Nemec-Bakk Ashley, Khaper Neelam, Martino Tami A

Abstract excerpt

Obesity and metabolic syndrome commonly underlie cardiovascular disease. ClockΔ19/Δ19 mice fed a normal diet develop obesity and metabolic syndrome; however, it is not known whether they develop or are resilient to cardiovascular disease. We found that ClockΔ19/Δ19 mice do not develop cardiac dysfunction, despite their underlying conditions. Moreover, in contrast to wild-type controls fed a high-fat diet (HFD),...

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Identifiers

PMID: 32986958
DOI: 10.1152/ajpheart.00462.2020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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