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Article

Calorie restriction and life-extending mutation downregulate miR-34a to facilitate lipid metabolism in the liver.

Experimental gerontology - 1 Sept 2024

Ashiqueali Sarah A, Zhu Xiang, Wiesenborn Denise S, Gesing Adam, Schneider Augusto, Noureddine Sarah A, Correa-Garcia Christian G, Masternak Michal M, Siddiqi Shadab A

Abstract excerpt

Ames dwarf mice (df/df) display delayed aging relative to their normal (N) siblings, living approximately 40-60 % longer. As such, investigating the mechanisms that enable these organisms to have extended lifespan is useful for the development of interventions to slow aging and deter age-related disease. Nonalcoholic fatty liver disease (NAFLD) is a condition that is characterized by the accumulation of excess...

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Identifiers

PMID: 38945410
DOI: 10.1016/j.exger.2024.112506
PMCID: PMC11418173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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