Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circadian Disruption Primes Myofibroblasts for Accelerated Activation as a Mechanism Underpinning Fibrotic Progression in Non-Alcoholic Fatty Liver Disease

8 Jun 2023

Abstract excerpt

Circadian rhythm governs many aspects of liver physiology and its disruption exacerbates chronic disease. CLOCKΔ19 mice disrupted circadian rhythm and spontaneously developed obesity and metabolic syndrome, a phenotype that parallels the progression of non-alcoholic fatty liver disease (NAFLD). NAFLD represents an increasing health burden with an estimated incidence of around 25% and is associated with an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diet, Metabolism, and Disease
Share to Liver Disease Diagnosis and Treatment
Share to Liver physiology and pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37371052
DOI: 10.3390/cells12121582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circadian Disruption Primes Myofibroblasts for Accelerated Activation as a Mechanism Underpinning Fibrotic Progression in Non-Alcoholic Fatty Liver DiseasePMID 37371052Read ↗

The Circadian Clock Controls Hepatic Stellate Cell Activation in Liver Fibrosis via a BMAL1/CK1ε/REV-ERBα/Transgelin Signaling PathwaySemantic proximity Read ↗

Circadian Clock and Liver CancerSemantic proximity Read ↗

Metabolic Reprogramming of Liver FibrosisSemantic proximity Read ↗

Hepatocyte Circadian Clocks Control Cholesterol Metabolism and Protect From Metabolic Dysfunction-Associated Steatohepatitis (MASH)Semantic proximity Read ↗

Current Insights into Liver Fibrosis: Epidemiological Patterns, Etiopathogenesis, Clinical Correlates, and Research AgendaSemantic proximity Read ↗

An Integrated Single-Cell Atlas Reveals Hepatic Stellate Cell Heterogeneity and Spatiotemporal Dynamics after Liver InjurySemantic proximity Read ↗

Non-alcoholic steatohepatitis disrupts diurnal liver transcriptome rhythms in miceSemantic proximity Read ↗

Nonalcoholic Steatohepatitis Disrupts Diurnal Liver Transcriptome Rhythms in MiceSemantic proximity Read ↗

Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling moduleSemantic proximity Read ↗

Circadian Regulation of Gene Expression and Metabolism in the LiverSemantic proximity Read ↗

MCD diet-induced steatohepatitis generates a diurnal rhythm of associated biomarkers and worsens liver injury in Klf10 deficient miceSemantic proximity Read ↗

Time-of-day-dependent variation of the hepatic transcriptome and metabolome is disrupted in non-alcoholic fatty liver disease patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.